Endocrine Abstracts

The gonadotrophin hormones comprise a common alpha subunit and a hormone specific beta subunit and their expression profiles differ during pituitary ontogeny. The transcriptional regulatory cascade that is required to mediate this is largely unknown. However, perturbation of the expression of homeodomain transcription factors, Paired-like homeodomain transcription factor 1 (Pitx1) and Homeobox gene expressed in embryonic stem cells 1 (Hesx1) disparately affects gonadotrophin g...